Research Specialist Shoichet Laboratory University of California, San Francisco Search JPF01999
The Department of Pharmaceutical Chemistry seeks candidates for a Specialist position in the Shoichet laboratory. This position will be hired at the Junior, Assistant Associate, or Full Specialist level dependent upon the applicant’s experience. The Shoichet lab seeks to bring chemical reagents to biology, combining computation and experiment. In a protein-centric approach, molecular docking, the lab discovers new ligands that complement protein structures. Using a ligand-centric approach, the lab also discovers new targets for known drugs and reagents. A focus for both is the discovery of reagents to modulate G-Protein Coupled Receptors (GPCRs).
This is a research position involving novel ligand discovery for orphan and therapeutic GPCRs, using computational docking and structure-based design. Against crystal structures and homology models of target receptors, a library of over 250 million make-on-demand molecules will be docked for physical fit. High ranking molecules will be sourced and tested experimentally. Active molecules emerging from the screen will be optimized for improved receptor fit, and the resulting molecules synthesized and again, tested for activity. It is anticipated that the researcher would also be involved in new methods development for molecular docking, improving our ability to find the active molecules from the hundreds-of-millions of inactives in the library.
Applicant is expected to be able to work independently and possess the ability to troubleshoot experiments when they don’t work. In addition, the applicant must possess the ability to analyze their data and clearly communicate their research techniques and results in written and oral formats suitable for publication. Specific activities associated with the position include, but are not limited to, the following:
Prosecution of large library molecular docking screens
Comparative modeling of protein-ligand complexes
Modeling based on crystallographic electron density
Detailed modeling of ligand-protein interactions
Structure-based design of novel ligands
Development of new computational methods for scoring and sampling in docking
Programming in fortran and related scripting languages.
Specialist appointed at the Junior rank must possess a bachelor’s degree (or equivalent) or at least four years of research experience.
Specialists appointed at the Assistant or Associate rank must have a minimum of a master’s degree (or equivalent) in life sciences field or at least five years of research experience
Specialists appointed at the Full rank must possess a terminal degree (or equivalent degree) in life sciences field or at least ten years of research experience
Detailed experience with ligand discovery
Knowledge of theory and experience with practice of large library docking screens
Excellent organizational skills
Excellent written and verbal presentation skills
Applicants must possess the required qualifications by the time of the appointment.
Programming skills in fortran
Experience with methods development for molecular docking
Experience with structure-based inhibitor design
PhD (or equivalent degree) in Medicinal Chemistry, Chemical Biology (or related field)
Postdoctoral experience in Medicinal Chemistry, Chemical Biology (or related field)
Salary and rank will be commensurate with the applicant’s experience and training.
UCSF seeks candidates whose experience, teaching, research, or community service has prepared them to contribute to our commitment of diversity and excellence.
The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.
Applicants must submit a cover letter and a curriculum vitae. Please apply online and submit these documents along with the contact information for two references to: https://aprecruit.ucsf.edu/apply/JPF01999.
Internal Number: JPF01999
About University of California, San Francisco
The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and high-quality patient care. It is the only UC campus in the 10-campus system dedicated exclusively to the health sciences.