UCSD Layoff from Career Appointment: Apply by 5/17/18 for consideration with preference for rehire. All layoff applicants should contact their Employment Advisor. Eligible Disability Counseling and Consulting services (DCC) or Special Selection clients should contact their Vocational Rehabilitation Counselor for assistance.
The Department of Pediatric has 18 divisions: Academic General Pediatrics, Child Development & Community Health; Allergy, Immunology and Rheumatology; Cardiology; Dermatology; Dysmorphology; Emergency Medicine; Endocrinology; Gastroenterology; Genetics; Genome Information Sciences; Hospital Medicine; Infectious Diseases; Neonatology; Nephrology; Pharmacology & Drug Discovery; Rehabilitation Medicine; and Respiratory Medicine.
As a part of the Division of Pharmacology and Drug Discovery, the Elizabeth Winzeler's Laboratory is interested in developing ways to treat and diagnose tropical diseases with a long-term interest in promoting development and reducing poverty. Most of our efforts are focused on malaria, a disease affecting 250-500 million people annually. We are developing genome-wide methods for discovering and tracking genes conferring resistance to drugs with antimalarial activity. We are also involved in discovering how thousands of chemical inhibitors with antimalarial activity are working to kill the parasites with a goal of discovering chemically validated targets and chemical tool compounds. Additionally, we are playing a role in public-private partnerships to develop new drugs to treat malaria. Finally, we are using somatic cell and host genetics to investigate host pathogen interactions. Our efforts involve chemical and traditional genetics, genomics, high-content imaging, screening and a network of national and international collaborators interested in public health.
Under the direction of the Principal Investigator or in collaboration with academic supervisors, incumbent takes charge of the execution of projects or major portions of research projects related to the identification of potential antimalarial activity using high throughput screening (HTS). This screening is essential to provide the foundation to the development of small molecule antimalarial compounds against exoerythrocytic and erythrocytic stages of Plasmodium falciparum, P. berghei and P. yoelii. Incumbent ensures the successful progress of the antimalarial HTS project at UCSD through supervision of all members of the small molecule screening group. This involves the planning, assigning and directing the work of other lab members including staff research associates. It also involves training of new hires to perform all relevant cellular assays. The incumbent utilizes state-of-the-art statistical tools and software to manage and analyze data. The incumbent takes complete control of the execution of laboratory phases of the major projects related to the antimalarial HTS; makes significant independent and innovative contributions to the successful prosecution of the projects related to antimalarial HTS.
This position is responsible for designing, trouble-shooting and optimizing experimental procedures as is necessary to achieve the stated objectives for the current UCSD antimalarial drug discovery projects. In order to ensure the success of the project, the incumbent will coordinate the dissemination of data to the relevant funding agencies and collaborators, including the Swiss based Medicines for Malaria Ventures (MMV), by weekly telephone conferences and writing of monthly and yearly reports and budget projections. The Staff research associate also coordinates compound transfer and Materia transfer agreements (MTAs) with academic and industry collaborators. The incumbent prepares complete written reports on all phases of experimental work involved in the HTS related research projects and submits them to MMV and the PI. These reports are used for major portions of articles prepared for publication as well as providing background and preliminary data for grant applications. Incumbent contributes to the preparation of grant applications, including, but not limited to the writing of sections based on the data generated in the execution of the research projects.
Advanced theoretical knowledge of infectious diseases, parasitology, malaria, mosquito biology, biochemistry and molecular biology. PhD in biological sciences, molecular parasitology and/or infectious diseases preferred.
Advanced demonstrated ability to perform scientific procedures including, Plasmodium culture and in vitro drug assays, molecular biology techniques, cloning, parasite transfection (P. falciparum and P. berghei), blottings, sequencing and genotyping (RFLP, microsatellites and single-nucleotide polymorphisms), drug efficacy studies in murine models, mosquit
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