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Department Name/Job Location:
This position is in the Department of Internal Medicine, Renal Division. This position is for the Medical School Campus.
This position is full-time and works approximately 40 hours per week.
An opportunity is immediately available for a Postdoctoral Research Associate at the Washington University Division of Nephrology. Endoplasmic reticulum (ER) dysfunction and protein misfolding disease is an emerging field. The overall goals of our research are to delineate the molecular mechanisms underlying ER stress-mediated kidney diseases, including nephrotic syndrome (NS), Alport syndrome, autosomal dominant tubulointerstitial kidney disease (ADTKD) and other acquired forms of ER disease, to develop ER stress biomarkers in human patients, and to identify ER stress modulators. (JCI Insight 2(23): e92896 2017; J Am Soc Nephrol. 27: 2974-2982 2016; J Am Soc Nephrol. 24: 1223-1233 2013; J Am Soc Nephrol. 22: 849-858 2011; two patent applications related to the discovery of ER stress biomarkers). The second focus in the laboratory is to study the crosstalk between podocytes and glomerular endothelial cells (GECs) or tubular cells and peritubular capillary ECs in a variety of kidney diseases, including NS and renal fibrosis.
We are using cutting-edge research approaches, including stably transfected or knock-down cells, molecular and cell biology, biochemistry, inducible transgenic, conditional knock-out and knock-in mouse models, human iPSCs derived from patients, and state-of-the-art in vitro & in vivo imaging techniques. We also have access to multiple kidney disease consortiums to acquire their genomic data, gene expression, histology from kidney biopsies, and urine samples.
The PI’s research has been funded by multiple grants from NIH, the Children’s Discovery Institute, American Society of Nephrology, Doris Duke Charitable Foundation, NEPTUNE etc. and industry. The lab environment is highly supportive and the position will be stable for at least 3-4 years.
PRIMARY DUTIES AND RESPONSIBILITIES:
Contribute intellectually and experimentally to the initiation and progression of the research projects.
Work independently to generate, analyze, and present experimental results.
Assist in the preparation of manuscripts and grant applications.
Help manage the essential functions of the laboratories.
PhD/MD in a relevant field is required.
Base pay commensurate with experience.
This position is eligible for full-time benefits.� Please visit our website at http://hr.wustl.edu to view a summary of benefits.
Internal Applicant Instruction:
Please attach a copy of your most current signed performance evaluation (completed within the last 18 months) to your online account. If you have not received a performance evaluation, you may provide two current signed letters of recommendation (written within the last 18 months), preferably to include one letter from either a current or recent former supervisor. To attach these documents, go to: My Career Tools, Add Attachment, Attachment Type – Performance Reviews or Letters of Recommendation.
Applicant Special Instructions:
If you are a career-oriented and highly motivated researcher who intends to be productive in the postdoc period and is willing to work hard, please email a CV, a cover letter and the names of three references to:
Y. Maggie Chen, MD, PhD
Assistant Professor of Medicine Division of Nephrology Washington University School of Medicine Box 8126 660 S. Euclid Avenue St. Louis, MO 63110
Washington University in St. Louis, a medium-sized, independent university, is dedicated to challenging its faculty and students alike to seek new knowledge and greater understanding of an ever-changing, multicultural world. The University offers more than 90 programs and almost 1,500 courses leading to bachelor's, master's and doctoral degrees in a broad spectrum of traditional and interdisciplinary fields, with additional opportunities for minor concentrations and individualized programs. The faculty is composed of scholars, scientists, artists and members of the learned professions. They serve society by teaching; by adding to the store of human art, creativity, understanding, and wisdom; and by providing direct services, such as health care.