The Gene Therapy Program (GTP) is entering a new era of unprecedented opportunity with great potential to reshape the face of medicine as we know it. Our discoveries have set the stage for successful treatments and possibly even cures for devastating genetic diseases.
The laboratory of Dr. Jim Wilson, at GTP of the University of Pennsylvania has been a leader in the development of innovative vector technology for close to three decades. We have emerged as the ‘go-to’ organization for public and private partners, who want to participate in the gene therapy space. Currently we are positioned to lead another round of vector innovation and establish pre-clinical and clinical proof-of-concept in therapeutic applications of in-vivo genome editing.
Our Vector Core is a state-of-the-art facility which provides vector-related materials and services in support of basic and translational research worldwide, producing vectors in support of IND-enabling research, conduct GLP assays, oversee CMO’s in vector production and is expanding to conduct state-of-the art process development.
Due to significant growth, the Vector Core is looking for a new, Research Specialist, Process Development (RSPD) to design, optimization, and scale-up of mammalian cell culture processes from laboratory to 1,000L scale.
As an RSPD, you will apply engineering and biological expertise to develop and optimize novel cell culture processes suitable for cGMP manufacturing. You will perform upstream cell culture activities ranging from cell seeding, media development and optimization, cell line development, and bioreactor operation. You will investigate and compare scalable AAV production systems, perform laboratory experiments including process validation, process range, process robustness, and troubleshooting studies. You will be involved in the development of in-process assays to monitor product quality and potency. This position offers the opportunity to interface internally with diverse functional areas. You will mentor new research staff within the Process Development group.
You will work both independently and as part of a team to accomplish project goals within specified timelines and will participate in technology transfer processes both to internal production groups and contracted manufacturers. You will be responsible for writing/reviewing batch records, SOPs, and process validation documents. You will serve as author/reviewer for relevant CMC sections of regulatory submissions, and ensure that all reports are completed in a timely fashion.
Internal Number: 32701
About University of Pennsylvania
Penn has a long and proud tradition of intellectual rigor and pursuit of innovative knowledge, begun by Benjamin Franklin in 1740. That tradition lives today through the creativity, entrepreneurship, and engagement of our faculty, students, and staff. Academic life at Penn is unparalleled, with an undergraduate student body of 10,000 from every U.S. state and around the world. The entering class of 2015 is the most talented and diverse in Penn's history. Consistently ranked among the top 10 universities in the country, Penn welcomes an additional 10,000 students to our top-ranked graduate and professional schools.